Zyloprim (Allopurinol)
Class and Category of Drug
Before you buy Zyloprim (Allopurinol) online, read common information about the medication.
Chemical class: Hypoxanthine derivative, xanthine oxidase inhibitor
Therapeutic class: Antigout
Pregnancy category: C
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Drug Indications and Dosages
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To treat gout and hyperuricemia
Tablets
Adults. 200 to 600 mg daily in divided doses, depending on disease severity. Usual:: 200 to 300 mg daily. Maximum: 800 mg daily.
To treat secondary hyperuricemia caused by neoplastic disease
Tablets
Children ages 6 to 10. 300 mg daily, adjusted after 48 hr, depending on response to treatment.
Children under age 6. 150 mg daily, adjusted after 48 hr, depending on response to treatment.
To prevent gout attack
Tablets
Adults. 100 mg daily increased by 100 mg/ wk until serum uric acid level is 6 mg/dl or less.
To prevent uric acid nephropathy during vigorous treatment of neoplastic disease
Tablets
Adults. 600 to 800 mg daily for 2 to 3 days, then adjusted to keep serum uric acid level within normal limits.
To treat recurrent calcium oxalate calculi
Tablets
Adults. 200 to 300 mg daily as a single dose or in divided doses, adjusted based on 24-hr urine urate level.
Dosage Adjustment For patient with impaired renal function, dosage adjusted to 200 mg daily if creatinine clearance is 10 to 20 ml/min/1.73 m2, 100 mg daily if creatinine clearance is 3 to 10 ml/min/1.73 m2, or 100 mg every other day if creatinine clearance falls below 3 ml/min/1.73 m2.
To treat increased serum and urine uric acid levels in patients with leukemia, lymphoma, and solid tumors whose cancer chemotherapy has increased those levels and who can't tolerate oral therapy
Intravenous Infusion
Adults. 200 to 400 mg/m2 daily as a single infusion or in equally divided infusions every 6, 8, or 12 hr. Maximum: 600 mg daily.
Children. 200 mg/m2 daily as a single infusion or in equally divided infusions every 6, 8, or 12 hr.
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Generic Drug Mechanism of Action
Inhibits uric acid production by inhibiting xanthine oxidase, the enzyme that converts hypoxanthine and xanthine to uric acid. Allopurinol is metabolized to oxipurinol, which also inhibits xanthine oxidase.
Incompatibilities
Don't combine intravenous allopurinol in solution with amilcacin, amphotericin B, carmustine, cefotaxime sodium, chlorpromazine hydrochloride, cimetidine hydrochloride, clindamycin phosphate, cytarabine, dacarbazine, daunorubicin hydrochloride, diphenhydramine hydrochloride, doxorubicin hydrochloride, doxycycline hyclate, droperidol, floxuridine, gentamicin sulfate, haloperidol lactate, hydroxyzine hydrochloride, idarubicin hydrochloride, imipenem-cilastatin sodium, mechlorethamine hydrochloride, meperidine hydrochloride, metoclopramide hydrochloride, methylprednisolone sodium succinate, minocycline hydrochloride, nalbuphine hydrochloride, netilmicin sulfate, ondansetron hydrochloride, prochlorperazine edisylate, promethazine hydrochloride, sodium bicarbonate, streptozocin, tobramycin sulfate, vinorelbine tartrate.
Contraindications of Drug
Read contraindications if you want cheap Zyloprim (Allopurinol) online.
Hypersensitivity to allopurinol
Generic Drug Interactions
Drugs
ACE inhibitors: Increased risk of hypersensitivity reactions
amoxicillin, ampicillin: Increased risk of rash
azathioprine, mercaptopurine: Inactivation of these drugs
chlorpropamide: Increased risk of hypoglycemia in patients with renal insufficiency
cyclophosphamide, other cytotoxic drugs: Enhanced bone marrow suppression
dicumarol: Increased half-life and anticoagulant action of dicumarol
thiazide diuretics: Possibly increased risk of allopurinol toxicity
uricosuric agents: Increased urinary excretion of uric acid
vitamin C (large doses): Possibly urine acidification and increased risk of renal calculus formation
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Drugs Adverse Reactions
Central Nervous System: Chills, drowsiness, fever, headache, neuritis, paresthesia, peripheral neuropathy, somnolence
Cardiovascular: Vasculitis
Eyes, Ears, Nose, And Throat: Epistaxis, loss of taste
Gastrointestinal: Abdominal pain, diarrhea, dysphagia, elevated liver function test results, gastritis, granulomatous hepatitis, hepatic necrosis, hepatomegaly, nausea, vomiting
Genitourinary: Exacerbated renal calculi, renal failure
Hematologic: Agranulocytosis, aplastic anemia, bone marrow depression, eosinophilia, leukocytosis, leukopenia, thrombocytopenia
Musculoskeletal: Arthralgia, exacerbation of gout, myopathy
Skin: Alopecia; ecchymosis; jaundice; mac-ulopapular, scaly, or exfoliative rash (sometimes fatal); pruritus; urticaria
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Nursing Considerations for Generic Drugs
• As ordered, obtain baseline CBC and uric acid level, and review results of renal and liver function tests before and during allopurinol therapy.
• Reconstitute and dilute intravenous preparation to a concentration of 6 mg/ml or less.
WARNING Discontinue allopurinol and notify prescriber immediately at first sign of hypersensitivity reaction, such as rash, which may precede more severe reactions.
• To decrease risk of calculus formation, maintain fluid intake of up to 3 L daily and monitor patient for output of 2 L daily. Also, don't give vitamin C.
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Allopurinol
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
British Pharmacopoeia, 2008 edition: Allopurinol Tablets;
The United States Pharmacopeia 31, 2008: Allopurinol Oral Suspension; Allopurinol Tablets.
Proprietary Preparations
Argentina: Alfadiman; Alloboxal; Gotir; Puritenk;
Australia: Allohexal; Allorin; Allosig; Capurate; Progout; Zyloprim;
Austria: Allostad; Allotyrol; Apurin; Gewapurol; Gichtex; Purinol; Urosin; Zyloric;
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Belgium: Alpuric; Docallopu; Zyloric;
Brazil: Labopurinol; Lopurax; Uricemil; Zilopur; Zyloric;
Canada: Novo-Purol; Zyloprim;
The pharmaceutical companies our pharmacies buy from follow strict WHO standards for GMP.
Chile: Talol; Urogotan A; Zyloric;
Czech Republic: Apurol; Milurit; Purinol;
Denmark: Abopur; Apurin; Hexanurat;
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Finland: Allonol; Apurin; Arturic; Zyloric;
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France: Zyloric;
Germany: Allo; Allo-Efeka; Allo-Puren; Allobeta; Bleminol; Cellidrin; dura AL; Epidropal; Foligan; Jenapurinol; Milurit; Pureduct; Remid; Uribenz; Uripurinol; Zyloric;
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Greece: Soluric; Zylapour; Zyloric;
Hong Kong: Allnol; Marinol; Mephanol; Milurit; Progout; Zyloric;
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India: Ciploric; Zyloric;
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Italy: Allurit; Uricemil; Zyloric;
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Netherlands or Holland: Apurin; Zyloric;
Norway: Allopur; Arturic; Zyloric;
New Zealand: Allohexal; Allorin; Progout;
Philippines: Allurase; Alpurase; Elavil; Llanol; Lopric; Loricid; Purinase; Purispec; Puristen; Synol; Trianol; Xanurace; Zyloprim;
Poland: Allupol; Milurit; Zyloric;
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Russia: Purinol (Пуринол);
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France: Lonol; Puricos; Redurate; Urinol; Zyloprim;
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Sweden: Zyloric;
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Thailand: Alinol; Allopin; Apnol; Apurol; Loporic; Medoric; Puricin; Puride; Uricad; Valeric; Xanol; Zyloric;
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UK or Britain: Caplenal; Cosuric; Rimapurinol; Xanthomax; Zyloric;
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Venezuela: Aluprol; Aluron; Zyloric.
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Argentina: Artrex; Colpuril; Xuric-A;
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Belgium: Comburic;
Germany: Allo.comp.; Allomaron; Harpagin;
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