Zyprexa (Olanzapine)
Class and Category of Drug
Before you buy Zyprexa (Olanzapine) online, read common information about the medication.
Chemical class: Thienobenzodiazepine derivative
Therapeutic class: Antipsychotic
Pregnancy category: C
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Drug Indications and Dosages
Before purchase Zyprexa (Olanzapine) online , you must read how it works.
To treat psychosis
Orally Disintegrating Tablets, Tablets
Adults. Initial: 5 to 10 mg daily. Usual:: 10 mg daily. Maximum: 20 mg daily.
To treat manic phase of acute bipolar disorder
Orally Disintegrating Tablets, Tablets
Adults. Initial: 10 to 15 mg daily; may be increased or decreased by 5 mg every 24 hr as needed and prescribed. Usual:: 5 to 20 mg daily for 3 to 4 wk. Maximum: 20 mg daily.
As adjunct to treat acute bipolar disorder
Orally Disintegrating Tablets, Tablets
Adults. Initial: 10 mg daily with lithium or valproate sodium; may be increased or decreased by 5 mg every 24 hr, as needed and prescribed. Usual:: 5 to 20 mg/day for 6 wk. Maximum: 20 mg daily.
Dosage Adjustment Initial dosage possibly reduced to 5 mg for debilitated patients, those prone to hypotension, and female nonsmokers over age 65.
To treat agitation associated with schizophrenia and bipolar mania
Intramuscular Injection
Adults. 5 to 10 mg p.r.n. Repeat as needed every 2 to 4 hr.
Dosage Adjustment
Dosage decreased to 5 mg for elderly patients and 2.5 mg for debilitated patients, those prone to hypotension, and female nonsmokers over age 65.
Contraindications of Drug
Read contraindications if you want cheap Zyprexa (Olanzapine) online.
Blood dyscrasias, bone marrow depression, cerebral arteriosclerosis, coma, coronary artery disease, hepatic dysfunction, high-dose CNS depressants, hypersensitivity to olanzapine or its components, hypertension, hypotension, myeloproliferative disorders, severe CNS depression, subcortical brain damage
Generic Drug Interactions
Drugs
anticholinergics: Increased anticholinergic effects, altered thermoregulation
antihypertensives: Increased effects of both drugs, increased risk of hypotension
benzodiazepines (parenteral): Increased risk of excessive sedation and cardiorespiratory depression
carbamazepine, omepmzole, rifampin: Increased olanzapine clearance
CNS depressants: Additive CNS depression, potentiated orthostatic hypotension
diazepam: Increased CNS depressant effects
fluvoxamine: Decreased olanzapine clearance
levodopa: Decreased levodopa efficacy
lorazepam (parenteral): Possibly increased somnolence with intramuscular olanzapine injection
Activities
alcohol use: Additive CNS depression, potentiated orthostatic hypotension smoking: Decreased blood olanzapine level
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Drugs Adverse Reactions
Central Nervous System: Abnormal gait, agitation, akathisia, altered thermoregulation, amnesia, anxiety, asthenia, dizziness, euphoria, fatigue, fever, headache, hypertonia, insomnia, nervousness, neuroleptic malignant syndrome, restlessness, somnolence, stuttering, suicidal ideation, tardive dyskinesia, tremor
Cardiovascular: Chest pain, hyperlipidemia, hypertension, hypotension, orthostatic hypotension, peripheral edema, tachycardia
Eyes, Ears, Nose, And Throat: Amblyopia, dry mouth, increased salivation, pharyngitis, rhinitis
Endocrine: Hyperglycemia, prolactin elevation
Gastrointestinal: Abdominal pain, constipation, dysphagia, hepatitis, increased appetite, nausea, thirst, vomiting
Genitourinary: Urinary incontinence, urinary tract infection
Hematologic: Agranulocytosis, leukopenia, neutropenia
Musculoskeletal: Arthralgia; back, joint, or limb pain; muscle spasms and twitching
Respiratory: Cough
Skin: Ecchymosis, photosensitivity, pruritus, urticaria
Other: Anaphylaxis, angioedema, flulike symptoms, weight gain
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Nursing Considerations for Generic Drugs
WARNING Olanzapine shouldn't be used for elderly patients with dementia-related psychosis because drug increases risk of death in these patients.
Reconstitute parenteral olanzapine by dissolving contents of vial in 2.1 ml sterile water to yield 5 mg/ml. Solution should be clear yellow. Use within 1 hour.
Inject intramuscular olanzapine slowly, deep into muscle mass.
Keep patient recumbent after intramuscular injection of olanzapine if drowsiness, dizziness, bradycardia, or hypoventialtion occurs. Don't let patient sit or stand up until blood pressure and heart rate have returned to baseline.
Monitor patient's blood pressure routinely during therapy because olanzapine may cause orthostatic hypotension.
Olanzapine may worsen such conditions as angle-closure glaucoma, benign prostatic hyperplasia, and seizures.
Assess daily weight to detect fluid retention.
Notify prescriber if patient develops tardive dyskinesia or urinary incontinence.
Be alert for and immediately report signs of neuroleptic malignant syndrome.
Watch patient closely (especially children, adolescents, and young adults), for suicidal tendencies, particularly when therapy starts and dosage changes, because depression may worsen temporarily during these times, possibly leading to suicidal ideation.
Monitor patient's lipid levels throughout therapy, as ordered, because olanzapine may cause significant elevations.
Monitor patient's blood glucose level routinely because olanzapine may increase risk of hyperglycemia.
Monitor CBC often during first few months of therapy, especially if patient has low WBC count or history of drug-induced leukopenia or neutropenia. If WBC count declines, and especially if neutrophil count drops below 1,000/mm3, expect olanzapine to be discontinued. If neutropenia is significant, also monitor patient for fever or other evidence of infection and provide appropriate treatment, as prescribed.
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Contraindications of Drug
Blood dyscrasias, bone marrow depression, cerebral arteriosclerosis, coma, coronary artery disease, hepatic dysfunction, high-dose CNS depressants, hypersensitivity to olanzapine or its components, hypertension, hypotension, myeloproliferative disorders, severe CNS depression, subcortical brain damage
Remember it if you buying Zyprexa (Olanzapine) online.
Olanzapine
Preparations
International Brand Drug Names
The information about drugs (tablets, pills, capsules, creams, solution, nasal spray, inhaler) around the world.
Proprietary Preparations
Argentina: Midax; Zyprexa;
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Multi-ingredient
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